Neocortical Disorganization and Autism

Title : Hierarchical cortical transcriptome disorganization in autism

Affiliations 1 Center for Applied Neuroscience, Department of Psychology, University of Cyprus, Nicosia, Cyprus 2 Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom 3 Department of Neuroscience, University of California, San Diego, San Diego CA, USA 4 Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA,...

Hierarchical cortical transcriptome disorganization in autism

BACKGROUND Autism spectrum disorders (ASD) are etiologically heterogeneous and complex. Functional genomics work has begun to identify a diverse array of dysregulated transcriptomic programs (e.g., synaptic, immune, cell cycle, DNA damage, WNT signaling, cortical patterning and differentiation) potentially involved in ASD brain abnormalities during childhood and adulthood. However, it remains u...

Patches of disorganization in the neocortex of children with autism.

BACKGROUND Autism involves early brain overgrowth and dysfunction, which is most strongly evident in the prefrontal cortex. As assessed on pathological analysis, an excess of neurons in the prefrontal cortex among children with autism signals a disturbance in prenatal development and may be concomitant with abnormal cell type and laminar development. METHODS To systematically examine neocorti...

Cultural Disorganization and Crime

Disorganization and Financial Collapse

Recently, Blanchard and Kremer (BK) argued that disorganization has led to the output decline in the former Soviet Union. In this paper we introduce liquidity and credit constraints into the BK model and show how these problems can alleviate the hold-up problem. We argue further that barter creates a hostage which allows to deal with disorganization when credit enforcement is prohibitively cost...